Study of a bi-monomeric Becker-Döring-type model (Mathieu Mezache, INRAE MaIAGE)

In order to provide an explanation for the damped oscillations surprisingly observed in Prion depolymerization experiments, a bi-monomeric variant of the seminal Becker-Doring seminal system is proposed. In this talk, we look at the mechanisms leading to these oscillations. We characterize the dynamics of the system in different kinetic phases: from the initial phase of high amplitude oscillations to progressive damping and convergence towards the unique stationary solution. This result is based on quantitative approximations of the main quantities of interest: the period of oscillations, the damping of oscillations corresponding to an energy loss and the number of oscillation cycles characterizing each kinetic phase.